| VII Conferencia Bienal Barcelona/Pittsburgh |
|
| La demencia hoy | 12-14 Mayo 2010 |
| VII Barcelona/Pittsburgh Biennial Conference |
|
| Dementia today | 12TH-14TH May 2010 |
Agenda
VI Simposio de Actualización en Demencias "Avances en el diagnóstico y el tratamiento de la enfermedad de Alzheimer"
Fecha
28-09-2010 al 28-09-2010
Lugar
Sala d'Actes - planta 10 - Hospital General Universitari Vall d'Hebron
Organizado por
Unitat de Trastorns de la Memòria de l'HUVH i Fundació ACE. Institut Català de Neurociències Aplicades
Bibliografía
Articulos
Down's Syndrome and Alzheimer's Disease: Two Sides of the Same Coin
Huntington Potter
Future NeurologyAño: 2008
Categoría: Down
Abstract
All Down's syndrome individuals develop Alzheimer's disease (AD) neuropathology by the age of 40 years. To unite the two diseases under one hypothesis, we have suggested that classical AD, both of the genetic and late-onset sporadic forms, might be promoted by small numbers of trisomy 21 cells developing during the life of the affected individual. Recent evidence from several laboratories will be presented, which strongly supports the trisomy 21 hypothesis that defects in mitosis, and particularly in chromosome segregation, may be a part of the AD process. Specifically, genetic mutations that cause familial AD disrupt the cell cycle and lead to chromosome aneuploidy, including trisomy 21, in transgenic mice and transfected cells; cells from both familial and sporadic AD patients exhibit chromosome aneuploidy, including trisomy 21. The possibility that many cases of AD are mosaic for trisomy 21 suggests novel approaches to diagnosis and therapy.
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