| VIII Conferencia Bienal Barcelona/Pittsburgh |
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| La demencia hoy | 23-25 Mayo 2012 |
| VIII Barcelona/Pittsburgh Biennial Conference |
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| Dementia today | 23TH-25TH May 2012 |
Magazin
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Agenda
Charla "La memoria y la atención. Cambios en la edad adulta" - Jornadas de Puertas Abiertas - Fundació ACE. Institut Català de Neurociències Aplicades
Fecha
22-09-2011 al 22-09-2011
Lugar
Centro Cívico Cotxeres de Sants - Barcelona - España
Organizado por
Fundació ACE. Institut Català de Neurociències Aplicades
Charla "Tipos de memoria y por qué se afectan"- "La respuesta social ante la demencia" - Jornadas de Puertas Abiertas - Fundació ACE. Institut Català de Neurociències Aplicades
Fecha
13-09-2011 al 13-09-2011
Lugar
Centro Cívico Can Deu - Barcelona - España
Organizado por
Fundació ACE. Institut Català de Neurociències Aplicades
"Ageing and Neurodegeneration"
Fecha
01-09-2011 al 04-09-2011
Lugar
Bergisch Gladbach - Alemania
Organizado por
DZNE, the German Center for Neurodegenerative Diseases and the Max Planck Institute for Biology of Ageing
Bibliografía
Articulos
Down's Syndrome and Alzheimer's Disease: Two Sides of the Same Coin
Huntington Potter
Future NeurologyAño: 2008
Categoría: Down
Abstract
All Down's syndrome individuals develop Alzheimer's disease (AD) neuropathology by the age of 40 years. To unite the two diseases under one hypothesis, we have suggested that classical AD, both of the genetic and late-onset sporadic forms, might be promoted by small numbers of trisomy 21 cells developing during the life of the affected individual. Recent evidence from several laboratories will be presented, which strongly supports the trisomy 21 hypothesis that defects in mitosis, and particularly in chromosome segregation, may be a part of the AD process. Specifically, genetic mutations that cause familial AD disrupt the cell cycle and lead to chromosome aneuploidy, including trisomy 21, in transgenic mice and transfected cells; cells from both familial and sporadic AD patients exhibit chromosome aneuploidy, including trisomy 21. The possibility that many cases of AD are mosaic for trisomy 21 suggests novel approaches to diagnosis and therapy.
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